When University of California at San Francisco (UCSF) Genentech Hall opened in 2003, there was one company in this sector in the city; by 2013, there were more than 100. The development of this campus also catalyzed the growth of infrastructure and commercial investment in a new neighborhood, including amenities that have made the area attractive for nearby residents. However, the campus and its growth have also led to stresses on local parking, transportation, and housing stock. Ultimately, this expansive project is the result of collaboration by visionaries across sectors. These partners worked with the community to create a campus that strengthens the University in its mission of "advancing health worldwide."

This case study is based on research conducted by MASS Design Group between February and March 2016. Funded by The Atlantic Philanthropies, this case illustrates how a large-scale capital project can have a dramatic effect on public institutions and the work they conduct. It also illuminates challenges and opportunities inherent in responding to inevitable institutional as well as external changes over time.